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Doctor's Best Double Strength SAM-e 400mg

30 tablets
Doctor's Best Double Strength SAM-e 400mg

Doctor’s Best SAMe contains the helpful chemical S-adenosylmethionine to promote positive mood, support joint mobility and comfort, and sustain healthy liver detoxification. This important substance is responsible for producing many important bodily compounds like neurotransmitters and different hormones. Each tablet contains Italian SAMe, the highest quality SAMe available in the market.

Supplement Facts

Serving Size: 1 Tablet
Servings Per Container: 30


Amount Per Serving

% Daily Value

S-Adenosyl Methionine

(from 800mg of SAM-e tosylate disulfate)

400 mg


† Daily Value not established.

Other Ingredients: Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

Suggested Use

Adults only. Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.


Individuals using antidepressant medications should consult with their prescribing Doctor prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAM-e. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.


The many benefits of Sam-e are useful for preserving emotional wellness, joint health, and efficient liver functions. Increased levels of Sam-e in the brain promote increased availability of the neurotransmitters serotonin and dopamine for effective mood regulation. A healthier mood diminishes periods of depression, apprehension, mood swings, anxiety, and other negative emotions. It also encourage adequate rest periods to rejuvenate the body and sustain healthy energy levels. Sam-e supplements protect joint health by helping maintain normal structure of cartilages. Stronger and more resilient cartilages and connective tissues reduce wear and tear of the joints. Additionally, it supports the body’s natural anti-inflammatory response and healing abilities. This chemical is related to effective liver detoxification for overall liver health. Sam-e supplements are often used to help the body cope more effectively with fatigue and other discomforts associated with ineffective liver functions. According to many Sam-e reviews, it may also help improve healthier pain tolerance and threshold to reduce the need for NSAIDs and avoid unwanted NSAID side effects.

Sam-e (S-adenosylmethionine) is not a vitamin, mineral, enzyme, or hormone, but is a synthetic chemical naturally occurring in the body. The liver is the organ responsible for sam-e production, which is reliable on Vitamin B12 and folic acid supply from the diet. Thus Vitamin B12 and folic acid deficiencies may lead to low concentrations of sam-e in the different organs that need it. When the liver produces low sam-e levels, Doctor’s Best sam-e is designed to increase the concentrations of SAM-e in the nervous system, liver, and joints. This exceptional molecule is a derivative of the amino acid Methionine involved in the synthesis of hormones and neurotransmitters. In the brain, SAM-e aids the production of Serotonin and Dopamine, neurotransmitters that elevate the mood. As an important methyl donor, it serves as a catalyst in the production of ephinephrine, glutathione, melatonin, and amino acids cysteine and taurine. Apart from being a methyl donor, SAM-e is also a sulfur donor responsible in the formation of proteoglycans in the connective tissues. Proteoglycans are the major part of the extracellular matrix of cells in the connective tissues that provide structural support. Despite its high involvement in different biochemical reactions occurring in the body, SAM-e is highly unstable and is prone to degradation upon exposure to conditions where there is heat, light, and even moisture. In order for it to be stable, SAM-e must be converted into salt. SAM-e salts are usually the SAM-e form commonly found in SAM-e supplements.