Product Information

L-Histidine is used to synthesise haemoglobin, a protein in the blood that transports oxygen and nutrients to the cells. It is also used in producing histamine, the chemical released when the body responds to allergens. Deficiency in this amino acid is also associated with Rheumatoid Arthritis (RA) and cataract.

Supplement Facts

Serving Size: 500mg
Servings Per Container: 200


Amount Per Serving

% Daily Value

L-Histidine HCl

500 mg


† Daily Value not established.

Other Ingredients: None

Suggested Use

Take 500mg (scant 1/8 tsp) daily.


For adults only. If you are pregnant, lactating, using prescription medicine or have a medical condition, consult your Doctor before taking this product.

  • L-Histidine is a conditionally essential amino acid. Children don’t produce this amino acid but it is essential for their growth and development, while adults manufacture L-Histidine in adequate amounts. It is abundantly found in plant and animal proteins in pork, poultry, cheese, and wheat germ. The body uses L-Histidine to manufacture important compounds like histamine and haemoglobin.
  • L-Histidine is used in the synthesis of histamine, the chemical released when the body responds to allergens. This mechanism according to experts improves the body’s responses to allergic reactions. When released, histamine triggers a series of physiological changes such as drop in blood pressure, increased production of stomach acids, dilation of capillaries, leakage of subcutaneous fluid causing itching and hives, and narrowing of the bronchial tubes.
  • Histidine is not just a building block of protein, it’s also a building block of haemoglobin, the compound responsible for delivering oxygen and nutrients to the cells. Histidine deficiency may lead to anemia, a condition characterized by low levels of haemoglobin in the blood. Signs and symptoms of anemia include fatigue, difficulty in breathing, paleness, dizziness, and tongue swelling. Adding more L-histidine in the diet supplies more raw materials for the synthesis of more haemoglobin enough to combat anemia.
  • People with Rheumatoid Arthritis are found to be low in Histidine both in the blood and in the synovial fluid. In fact, according to one study, L-Histidine is the only amino acid consistently low in cases of RA. Rheumatoid Arthritis is a chronic disease characterized by inflammation in the joints causing severe pain and immobility in the wrists, fingers, ankles, and feet. Adding more histidine in the diet or by taking Histidine supplements may correct the deficiency and help manage the symptoms of Rheumatoid Arthritis.
  • In animal studies, the subjects who were deprived of this building block of protein developed cataract faster. Cataract or clouding of the eye is a progressive condition that leads to blurred vision and blindness. In fact, it is the leading cause of blindness in the world. Eye drops formulated to prevent cataract contains L-Histidine.

L-Histidine or simply Histidine is one an amino acid that is neither essential nor non-essential. This building block of protein is considered semi-essential or conditionally essential. It becomes such because children’s body doesn’t manufacture L-Histidine, but it is important for growth and development. It should be supplied to them by eating Histidine rich foods or through L-Histidine powder and other supplements. Meanwhile, adults produce it in reasonable amounts enough to sustain the body’s needs.  L-Histidine is found abundantly in protein-rich foods such as pork, chicken and other poultry, tuna, tofu, spirulina, sunflower seeds, cheese, and wheat germ.

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